Downbeat nystagmus can be treated with 4-aminopyridine, 3,4-diaminopyridine, or clonazepam.
Upbeat nystagmus can be reduced with memantine, 4-aminopyridine, or baclofen.
Torsional nystagmus may respond to gabapentin.
Acquired pendular nystagmus in patients with multiple sclerosis is often partially suppressed by gabapentin or memantine.
Although acquired periodic alternating nystagmus is often completely suppressed by baclofen, memantine can be effective in refractory cases.
Seesaw nystagmus can be reduced with alcohol, clonazepam, or memantine.
Other treatment options for nystagmus include botulinum toxin injections into the extraocular muscles or retrobulbar space. Electro-optical devices are currently being developed, in order to noninvasively negate the visual consequences of nystagmus.