Multiple Sclerosis
(MS) is the most common progressive and disabling neurological
condition affecting young adults in the world today. From a genetic
point of view, MS is a complex disorder resulting from the combination
of genetic and non-genetic factors. We aimed to identify previously
unidentified loci conducting a new Genome-wide association study (GWAS) of Multiple Sclerosis
(MS) in a sample of 296 MS cases and 801 controls from the Spanish
population. Meta-analysis of our data in combination with previous GWAS
was done. A total of 17 GWAS-significant single nucleotide polymorphisms corresponding to three
different loci were identified:HLA (human leucocyte antigen=transplantation antigen), IL2RA (interleukin 2 receptor) , and 5p13.1 (Identify of gene at this location is unknown). All three have
been previously reported as GWAS-significant. We confirmed our
observation in 5p13.1 for rs9292777 using two additional independent
Spanish samples to make a total of 4912 MS cases and 7498 controls
(ORpooled = 0.84; 95%CI: 0.80-0.89; p = 1.36×10-9). This SNP differs
from the one reported within this locus in a recent GWAS. Although it is
unclear whether both signals are tapping the same genetic association,
it seems clear that this locus plays an important role in the
pathogenesis of MS.
There are no over 50 non-HLA gnes that have been linked to susceptibility to MS. What does 5p13.1 mean?. It is just a location
Chromosome which carry the genetic information have one long arm called q and a short arm called p. So this gene is located on chromosome 5, the p arm. The chromosomes have banding on them which is called cytogentics and the gene is in band 13.1. Now all they need to do is find the gene and see what it does
Labels: Genetics